![]() The CDC surveillance criteria requires 2 out of 3 IgM bands and/or 5 out of 10 IgG bands for a positive test result. In this two-step approach, the Western blot detects antibodies to several proteins of B. If the ELISA test is positive or equivocal, this test is usually performed to confirm the diagnosis. Unfortunately, with a negative ELISA, most patients are definitively told they do not have Lyme without any further inquiry. Studies show that the ELISA test generates false negative results approximately half of the time. Enzyme-linked immunosorbent assay (ELISA) test detects antibodies to B.The CDC recommends that doctors first order an ELISA to screen for Lyme disease and then confirm Lyme disease with a Western blot. The CDC currently recommends a two-step testing process for Lyme disease that was developed for surveillance purposes, the enzyme-linked immunosorbent assay (ELISA) and the Western blot. ![]() However, if a patient tests positive using the CDC’s standards, this may help patients receive appropriate treatment and insurance coverage. As detailed more fully below, the CDC criteria is deeply flawed. ![]() After you’ve had an infection for a period of time, IgG antibodies may be generated and could indicate the presence of a later stage or persistent infection. The body produces IgM antibodies in response to a recent or active infection. Typical testing for Lyme disease measures IgM and IgG antibodies. Based on available testing for Lyme disease, it can still be difficult to determine who has the illness, the most effective course of treatment, and when treatment can be discontinued. ![]()
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